ANTIHYPERTENSIVE EFFECT OF 19-ACETYLENIC-DEOXYCORTICOSTERONE IN INBRED SALT-SENSITIVE RATS

被引：8

作者：

AZAR, ST ^{[1
]}

MELBY, JC ^{[1
]}

GRIFFING, GT ^{[1
]}

JOHNSTON, JO ^{[1
]}

机构：

[1] BOSTON UNIV HOSP,MED CTR,EVANS MEM DEPT CLIN RES,ENDOCRINOL & METAB SECT,BOSTON,MA 02218

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1992年 / 5卷 / 06期

关键词：

SALT-SENSITIVE RATS; 19-NOR-DEOXYCORTICOSTERONE; DEOXYCORTICOSTERONE; CORTICOSTERONE; ADRENAL GLAND; 19-ACETYLENIC-DEOXYCORTICOSTERONE;

D O I：

10.1093/ajh/5.6.372

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Rats susceptible to the hypertensive effect of dietary salt (SS/Jr) have excess 19-nor-deoxycorticosterone (19-nor-DOC) compared with salt-resistant control rats (SR/Jr). 19-Nor-deoxycorticosterone is a hypertensinogenic mineralocorticoid believed to contribute to the salt sensitivity of SS/Jr. 19-Acetylenic-deoxycorticosterone (19-Ac-DOC), an inhibitor of 19-nor-DOC biosynthesis, was evaluated for its antihypertensive effect in 20 hypertensive female SS/Jr rats. At 60 days of age, the rats were started on a high-salt diet (8% NaCl); then, at 120 days, the 10 surviving rats were divided into two groups. Group 1 included five animals with blood pressure +/- standard error (BP +/- SE) of 208 +/- 2 mm Hg that had 19-Ac-DOC implants (1 mg released over 10 days). Group 2 consisted of five animals with a BP of 204 +/- 2 mm Hg that had placebo implants (vehicle only). At 130 days, when another set of pellets was implanted, four rats were still alive in group 1 (BP 165 +/- 5 mm Hg) and none in group 2. At 140 days, the four surviving rats had a BP of 157 +/- 2 mm Hg. Finally, at 150 days, after 10 days off any 19-Ac-Doc, only two rats remained alive (BP 200 +/- 0 mm Hg). Urinary corticosterone +/- SE, DOC +/- SE, and 19-nor-DOC +/- SE before the first implant were 10 +/- 3, 16 +/- 5, and 42 +/- 14-mu-g/week, respectively, and 7 +/- 2, 13 +/- 5, 23 +/- 13-mu-g/week, respectively, after the second implant. 19-Nor-deoxy-corticosterone, but not DOC and corticosterone, was reduced after the implants (P < .05). This suggests that 19-Ac-DOC lowers BP and improves the survival in hypertensive salt-sensitive rats, possibly through the inhibition of 19-nor-DOC synthesis.

引用

页码：372 / 377

页数：6

共 44 条

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