PREPARATION OF ETHENYL AND OXIRANOL CARBAMATE AND THEIR (2-H-2(2))-DERIVATIVES USING SELENIUM CHEMISTRY - THERMOLYSIS OF OXIRANOL CARBAMATE AND REACTION WITH ADENOSINE

被引：2

作者：

BLEASDALE, C

GOLDING, BT

KITSON, SL

机构：

[1] Department of Chemistry, University of Newcastle, Newcastle upon Tyne, NE1 7RU, Bedson Building

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 02期

关键词：

VINYL CARBAMATE; OXIRANE; URETHANE; SELENIUM; DIMETHYLDIOXIRANE;

D O I：

10.1016/S0960-894X(01)80131-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ethenyl carbamate was obtained by selenoxide fragmentation of 2-phenylselenylethyl carbamate. Base-catalysed exchange of ethyl phenylselenylacetate in methanol-OD gave methyl [H-2(2)]phenylselenylacetate from which [2-H-2(2)]ethenyl carbamate and [2-H-2(2)]oxiranol carbamate were derived. Thermolysis of oxiranol carbamate in eg acetone gave 4-hydroxy-1,3-axazolidin-2-one and 3H-1,3-oxazol-2-one.

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页码：291 / 296

页数：6

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