NUCLEAR-LOCALIZATION OF ANTI-HU ANTIBODY IS NOT ASSOCIATED WITH IN-VITRO CYTOTOXICITY

被引：52

作者：

HORMIGO, A

LIEBERMAN, F

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,NEW YORK,NY 10021

[2] MEM SLOAN KETTERING CANC CTR,GEORGE C COTZIAS LAB NEUROONCOL,NEW YORK,NY 10021

[3] CORNELL UNIV,COLL MED,DEPT NEUROL & NEUROSCI,NEW YORK,NY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1994年 / 55卷 / 02期

关键词：

ANTI-HU ANTIBODY; ANTIBODY INTERNALIZATION; CELL GROWTH; CYTOTOXICITY; PARANEOPLASTIC ENCEPHALOMYELONEUROPATHY;

D O I：

10.1016/0165-5728(94)90011-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IgG fractions of sera containing anti-Hu antibodies or control sera were incubated with Hu-positive and Hu-negative cell lines. Anti-Hu IgG specifically localized in the nucleus of Hu-positive cells. Anti-Hu-positive and control sera were incubated with Hu-positive cells and human complement or peripheral blood mononuclear cells. Hu antibody caused neither complement-mediated lysis nor augmented antibody-dependent cell-mediated cytotoxicity. Anti-Hu IgG did not affect proliferation of Hu-positive cells. Anti-Hu antibodies may not play a direct role in tissue injury in patients with paraneoplastic encephalomyeloneuropathy and anti-Hu antibodies.

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页码：205 / 212

页数：8

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