CHRONIC SEQUELAE OF NON-A-HEPATITIS, NON-B-HEPATITIS

被引:274
作者
BERMAN, M
ALTER, HJ
ISHAK, KG
PURCELL, RH
JONES, EA
机构
[1] NIH, CTR CLIN, DEPT BLOOD BANK, BETHESDA, MD 20014 USA
[2] NIAMDD, LIVER UNIT, BETHESDA, MD 20014 USA
关键词
D O I
10.7326/0003-4819-91-1-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
26 of 388 patients (6.7%) followed prospectively after open-heart surgery developed non-A, non-B hepatitis. Of these 26, 12 had an elevated (often fluctuating) serum alanine aminotransferase (SGPT) for greater than 1 year. Liver biopsy, done in eight of 12, showed chronic active hepatitis in six and chronic persistent hepatitis in two; one patient with chronic active hepatitis had early cirrhosis. Anicteric patients with peak SGPT greater than 300 IU/L were at a greater risk of developing chronic hepatitis. Chronic non-A, non-B hepatitis was symptomatically mild and unaccompanied by physical signs or laboratory evidence of autoimmune disease or severe chronic liver disease. In all 12 patients there was spontaneous improvement in serum transaminase over a period of 1 to 3 years, and four patients had sustained normalization of SGPT. Thus chronic active hepatitis is a common sequela of acute non-A, non-B hepatitis but may have a better prognosis than chronic active hepatitis of other causes.
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页码:1 / 6
页数:6
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