SIA-B1 AND I-ANTIGENS RECOGNIZED BY MYCOPLASMA-PNEUMONIAE-INDUCED HUMAN COLD AGGLUTININS

被引：11

作者：

ROELCKE, D

KREFT, H

NORTHOFF, H

GALLASCH, E

机构：

[1] UNIV GOTTINGEN,TRANSFUS MED ABT,W-3400 GOTTINGEN,GERMANY

[2] UNIV ULM,DEUTSCH ROTES KREUZ BLUTSPENDEZENT,W-7900 ULM,GERMANY

[3] UNIV ULM,TRANSFUS MED ABT,W-7900 ULM,GERMANY

来源：

TRANSFUSION | 1991年 / 31卷 / 07期

关键词：

D O I：

10.1046/j.1537-2995.1991.31791368339.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Postinfection cold agglutinins (CAs) with anti-Sia-b1 (i.e., anti-Sialo-branched) specificity frequently occurring together with anti-I CAs recognize antigenic determinants that are present on O(h) red cells and are partially destroyed by endo-beta-galactosidase on the red cell surface. They differ markedly from the monoclonal anti-Sia-b1 FI CA, which recognizes an epitope not expressed on O(h) cells, and resistant to the enzyme. On the other side, Sia-b1 determinants reacting with postinfection CAs share the characteristics of I determinants, with the exception that Sia-b1 determinants require sialyl groups as an immunodominant component. Five sera containing coexisting anti-Sia-b1 and anti-I CAs were tested against O(h) and enzyme-treated group O red cells. The results are consistent with a postinfection autoimmune response against a sialo-type 2 structure common for Sia-b1 and I determinants, which could serve as a receptor for Mycoplasma pneumoniae.

引用

页码：627 / 630

页数：4

共 19 条

[1] THE BLOOD-GROUP II SYSTEM - A CARBOHYDRATE ANTIGEN SYSTEM DEFINED BY NATURALLY MONOCLONAL OR OLIGOCLONAL AUTOANTIBODIES OF MAN [J].