ENANTIOSELECTIVE SYNTHESIS OF 6-CYCLOHEPTENE-1,3,5-TRIOL DERIVATIVES BY ENZYMATIC ASYMMETRIZATION

被引：50

作者：

JOHNSON, CR

GOLEBIOWSKI, A

MCGILL, TK

STEENSMA, DH

机构：

[1] Department of Chemistry, Wayne State University Detroit

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 23期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(00)78794-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from cycloheptatriene, 3,5-cycloheptadienol (1) has been prepared and elaborated to meso-6-(t-butyldimethylsilyloxy)-2-cycloheptene-1,4-diols (3 and 6). Enzymatic asymmetrization of these diols with Pseudomonas cepacia lipase in isopropenyl acetate provides optically pure skipped triol derivatives 4a and 7a.

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页码：2597 / 2600

页数：4

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