BIOREDUCTIVE DRUGS AS POSTIRRADIATION SENSITIZERS - COMPARISON OF DUAL FUNCTION AGENTS WITH SR-4233 AND THE MITOMYCIN-C ANALOG-EO9

被引：45

作者：

ADAMS, GE

STRATFORD, IJ

EDWARDS, HS

BREMNER, JCM

COLE, S

机构：

[1] Medical Research Council Radiobiology Unit, Chilton, Didcot

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1992年 / 22卷 / 04期

基金：

英国医学研究理事会;

关键词：

RADIOSENSITIZATION; HYPOXIA; BIOREDUCTIVE DRUGS;

D O I：

10.1016/0360-3016(92)90510-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Various bioreductive drugs that are potent hypoxic cell cytotoxins can also function as effective potentiators of radiation action when administered in vivo post irradiation. There is evidence that a contributory mechanism to this potentiation is enhanced sensitivity to the bioreductive drugs exhibited by cells that are damaged sublethally by radiation.

引用

收藏

页码：717 / 720

页数：4

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