CLONING OF THE MOUSE HSP25 GENE AND AN EXTREMELY CONSERVED HSP25 PSEUDOGENE

被引：30

作者：

FROHLI, E ^{[1
]}

AOYAMA, A ^{[1
]}

KLEMENZ, R ^{[1
]}

机构：

[1] UNIV HOSP ZURICH,DEPT PATHOL,DIV CANC RES,SCH MELZBERGSTR 12,CH-8091 ZURICH,SWITZERLAND

来源：

GENE | 1993年 / 128卷 / 02期

关键词：

GENOMIC CLONE; HEAT-SHOCK PROTEIN; INTRONS; HOMOLOGIES TO HUMAN HSP27 GENE;

D O I：

10.1016/0378-1119(93)90574-M

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A genomic clone of the murine gene encoding the small heat-shock protein, Hsp25, was isolated. The coding region is interrupted by two introns of 128 bp and approximately 600 bp at identical positions as the human hsp27 gene. The 5' flanking regions of the mouse and human genes are very strongly conserved and contain several sequence motives for the transcription factors, HSF and Spl. In the same screen we also isolated a hsp25 pseudogene. The sequence conservation between this pseudogene and hsp25 cDNA is very high (99%) indicating that this pseudogene emerged very recently.

引用

页码：273 / 277

页数：5

共 34 条

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