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HYPOXIA, PAF, AND NECROTIZING ENTEROCOLITIS

被引：21
作者：
CAPLAN, MS
SUN, XM
HSUEH, W
机构：
[1] NORTHWESTERN UNIV,CHILDRENS MEM HOSP,SCH MED,DEPT PEDIAT,CHICAGO,IL 60614
[2] NORTHWESTERN UNIV,CHILDRENS MEM HOSP,SCH MED,DEPT PATHOL,CHICAGO,IL 60614
来源：
LIPIDS | 1991年 / 26卷 / 12期
关键词：
D O I：
10.1007/BF02536562
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Necrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet-activating factor (PAF) on intestinal blood flow and intestinal necrosis, and implicate PAF as an important mediator in hypoxia-induced intestinal injury. Finally we provide evidence that PAF may be important in neonatal NEC.
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页码：1340 / 1343
页数：4
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