TREATMENT OF MYOTONIA WITH ANTIARRHYTHMIC DRUGS

被引：86

作者：

KWIECINSKI, H ^{[1
]}

RYNIEWICZ, B ^{[1
]}

OSTRZYCKI, A ^{[1
]}

机构：

[1] WARSAW ACAD MED & HOSP,DEPT CARDIOL,PL-02097 WARSAW,POLAND

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1992年 / 86卷 / 04期

关键词：

MYOTONIC DISORDERS; TREATMENT; ANTIARRHYTHMIC DRUGS;

D O I：

10.1111/j.1600-0404.1992.tb05103.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects of disopyramide, phenytoin, mexiletine, and tocainide were compared in 30 patients with myotonic disorders. The severity of myotonia was assessed by clinical and electromyographic criteria at the end of each treatment phase lasting four weeks. Mexiletine (MXT) and tocainide (TCD) were found to be the most potent antimyotonic agents. The antimyotonic efficacy of MXT and TCD is explained by their fast-blocking effect on voltage-dependent sodium channels in the muscle membrane. The benefits of myotonia control with pharmacological agents must be weight against the risk of therapy in the individual patient. Because of the risks of hematologic problems, TCD is not recommended by us for the treatment of myotonia.

引用

页码：371 / 375

页数：5

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