3 MONOFLUORINATED SMALL MOLECULES - ORTHO-FLUOROPHENYLGLYCINE, METHYL 4-(FLUOROCARBONYL)BENZOATE AND 16-ALPHA-FLUORO-ALPHA-ESTRADIOL 3-METHYL ETHER

被引：10

作者：

BURNS, JH

HAGAMAN, EW

机构：

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1993年 / 49卷

关键词：

D O I：

10.1107/S0108270193000605

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Amino-2-(2-fluorophenyl)acetic acid (ortho-fluorophenylglycine) consists of a planar acetate anion with a fluorophenyl group attached to the alpha C atom at a dihedral angle of 105.5-degrees. All three amino H atoms form hydrogen bonds to carboxylate O atoms of three adjacent molecules in the crystal. Methyl 4-(fluorocarbonyl)benzoate has a planar phenylfluorocarbonyl group and its planar carboxylate group is rotated by 6-degrees from it. The estradiol 3-methyl ether, 16alpha-fluoro-3-methoxyestra-1,3,5(10)-trien-17alpha-ol, has the well known structure for the estradiol moiety. The alcoholic H atom is hydrogen bonded to the adjacent F atom of the molecule. There are no intermolecular hydrogen bonds.

引用

页码：1393 / 1396

页数：4

共 16 条

[1] CRYSTAL STRUCTURE OF TEREPHTHALIC ACID [J].

BAILEY, M ;

BROWN, CJ .

ACTA CRYSTALLOGRAPHICA, 1967, 22 :387-&

[2] CONFORMATIONAL STUDIES ON OLIGOMETHYLENE GLYCOL DERIVATIVES AND RELATED COMPOUNDS .5. CRYSTAL AND MOLECULAR-STRUCTURE OF METHYL TEREPHTHALATE [J].

BRISSE, F ;

PEREZ, S .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1976, 32 (JUL15) :2110-2115

[3] CRYSTAL AND MOLECULAR STRUCTURE OF ESTRADIOL HEMIHYDRATE [J].

BUSETTA, B ;

HOSPITAL, M .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, 1972, B 28 (FEB15) :560-&

[4] CRYSTAL AND MOLECULAR STRUCTURE OF ESTRADIO-PROPANOL COMPLEX [J].

BUSETTA, B ;

COURSEILLE, C ;

GEOFFRE, S ;

HOSPITAL, M .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, 1972, B 28 (MAY15) :1349-+

[5] STRUCTURE OF CRYSTALLINE COMPLEX ESTRADIOL - UREA (1-1) [J].

DUAX, WL .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, 1972, B 28 (06) :1864-&

[6]

FRENZ BA, 1983, ENRAF NONIUS STRUCTU

[7]

GO K, 1981, AM CRYSTALLOGR ASS A, V9, P33

[8] C-13-P-31 CROSS POLARIZATION BETWEEN ISOLATED SPIN PAIRS IN ORGANOPHOSPHORUS SUBSTANCES - INTRAMOLECULAR STRUCTURE AND INTERNUCLEAR DISTANCE DETERMINATIONS IN SPINNING SOLIDS [J].

HAGAMAN, EW ;

HO, PC ;

BROWN, LL ;

SCHELL, FM ;

WOODY, MC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (21) :7445-7450

[9]

HAGAMAN EW, 1993, IN PRESS FUEL

[10] THE CHEMISTRY OF SULFUR TETRAFLUORIDE .2. THE FLUORINATION OF ORGANIC CARBONYL COMPOUNDS [J].

HASEK, WR ;

SMITH, WC ;

ENGELHARDT, VA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (03) :543-551

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