AGGREGATIVE PROPERTIES OF GANGLIOSIDES IN SOLUTION

被引：132

作者：

SONNINO, S ^{[1
]}

CANTU, L ^{[1
]}

CORTI, M ^{[1
]}

ACQUOTTI, D ^{[1
]}

VENERANDO, B ^{[1
]}

机构：

[1] UNIV PAVIA, DEPT ELECTR, I-27100 PAVIA, ITALY

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1994年 / 71卷 / 01期

关键词：

GANGLIOSIDES; AGGREGATION PROPERTIES; CRITICAL MICELLAR CONCENTRATION; GANGLIOSIDE-PROTEIN INTERACTIONS;

D O I：

10.1016/0009-3084(94)02304-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aggregative properties of gangliosides in diluted aqueous solutions are discussed on the basis of simple and well-established thermodynamic concepts. Theoretical assumptions are compared with experimental data obtained, mainly by scattering techniques, on GM3, GM2, GM1, GD1a, GalNAc-GD1a, GD1b, GD1b lactone and GT1b gangliosides, all containing ceramide portions of similar composition, and on GM1 molecular species containing different well-defined ceramide structures. We also report on mixed aggregates with amphiphilic compounds and on the ganglioside aggregate-soluble protein interaction effects which give rise to very stable lipoproteic complexes of well-defined ganglioside-protein composition.

引用

页码：21 / 45

页数：25

共 125 条

[1] 3-DIMENSIONAL STRUCTURE OF THE OLIGOSACCHARIDE CHAIN OF GM1 GANGLIOSIDE REVEALED BY A DISTANCE-MAPPING PROCEDURE - A ROTATING AND LABORATORY FRAME NUCLEAR OVERHAUSER ENHANCEMENT INVESTIGATION OF NATIVE GLYCOLIPID IN DIMETHYL-SULFOXIDE AND IN WATER DODECYLPHOSPHOCHOLINE SOLUTIONS [J].