NEUROANATOMICAL CHARACTERIZATION OF A NEW MUTANT RAT WITH DOPAMINE DEPLETION IN THE SUBSTANTIA-NIGRA

被引：16

作者：

CLARKE, DJ ^{[1
]}

PAYNE, AP ^{[1
]}

机构：

[1] UNIV GLASGOW,DEPT ANAT,GLASGOW G12 8QQ,SCOTLAND

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1994年 / 6卷 / 05期

基金：

英国惠康基金;

关键词：

TYROSINE HYDROXYLASE IMMUNOCYTOCHEMISTRY; STRIATUM; PARKINSONS DISEASE;

D O I：

10.1111/j.1460-9568.1994.tb01000.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A new mutant rat strain with movement disorders has arisen spontaneously in a closed colony of Albino - Swiss rats at the Department of Anatomy, Glasgow University. The animals possess a progressive locomotor disorder which is first apparent at around post-natal day 10. We here report that tyrosine hydroxylase immunocytochemistry demonstrates that these mutants have profound depletions in dopaminergic systems in the substantia nigra and corresponding areas of neostriatum.

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页码：885 / 888

页数：4

相关论文

共 14 条

[1] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].

ALBIN, RL ;

YOUNG, AB ;

PENNEY, JB .

TRENDS IN NEUROSCIENCES, 1989, 12 (10) :366-375

[2] THE NEOSTRIATAL MOSAIC - COMPARTMENTAL DISTRIBUTION OF CALCIUM-BINDING PROTEIN AND PARVALBUMIN IN THE BASAL GANGLIA OF THE RAT AND MONKEY [J].

GERFEN, CR ;

BAIMBRIDGE, KG ;

MILLER, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8780-8784

[3] 1-METHYL-4-PHENYL-1,2,3,6-TETRA-HYDROPYRIDINE-INDUCED PARKINSONIAN SYNDROME IN MACACA-FASCICULARIS - WHICH MIDBRAIN DOPAMINERGIC-NEURONS ARE LOST [J].

GERMAN, DC ;

DUBACH, M ;

ASKARI, S ;

SPECIALE, SG ;

BOWDEN, DM .

NEUROSCIENCE, 1988, 24 (01) :161-174

[4]

GRAYBIEL AM, 1990, J NEUROSCI, V10, P720

[5]

HOKFELT T, 1980, NEUROSCIENCE, V5, P2093, DOI 10.1016/0306-4522(80)90127-x

[6] USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].

HSU, SM ;

RAINE, L ;

FANGER, H .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580

[7] MPTP - CURRENT CONCEPTS AND CONTROVERSIES [J].

LANGSTON, JW ;

IRWIN, I .

CLINICAL NEUROPHARMACOLOGY, 1986, 9 (06) :485-507

[8]

Lyon M., 1989, GENETIC VARIANTS STR

[9] WEAVER MUTATION HAS DIFFERENTIAL-EFFECTS ON THE DOPAMINE-CONTAINING INNERVATION OF THE LIMBIC AND NONLIMBIC STRIATUM [J].

ROFFLERTARLOV, S ;

GRAYBIEL, AM .

NATURE, 1984, 307 (5946) :62-66

[10]

SCHMIDT MJ, 1982, J NEUROSCI, V2, P376