TUMOR ANGIOGENESIS FACTOR (TAF) AND ITS NEUTRALIZATION BY A XENOGENEIC ANTISERUM

被引：66

作者：

PHILLIPS, P

KUMAR, S

机构：

[1] Paediatric Oncology Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, Wilmslow Road, Withington

来源：

INTERNATIONAL JOURNAL OF CANCER | 1979年 / 23卷 / 01期

关键词：

D O I：

10.1002/ijc.2910230115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour angiogenesis factor (TAF) has been extracted from a variety of animal and human tumours. Its ability to induce neovascularization in two bioassays, viz. rat air‐sac and chick chorio‐allantoic membrane, is demonstrated. Similar extracts from normal tissues fail to induce angiogenesis. TAF extracts have been used to raise a xenogeneic antiserum, the specificity of which was investigated using classical immunological methods. Its ability to neutralize the biological activity of TAF using the two in vivo assays, was also demonstrated. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：82 / 88

页数：7

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