NUCLEOTIDE-SEQUENCE DETERMINATION OF CHICKEN GLUCAGON PRECURSOR CDNA - CHICKEN PREPROGLUCAGON DOES NOT CONTAIN GLUCAGON-LIKE PEPTIDE-II

被引：41

作者：

HASEGAWA, S

TERAZONO, K

NATA, K

TAKADA, T

YAMAMOTO, H

OKAMOTO, H

机构：

[1] TOHOKU UNIV,SCH MED,DEPT BIOCHEM,SENDAI,MIYAGI 980,JAPAN

[2] KOBE UNIV,FAC AGR,DEPT ANIM NUTR,KOBE 657,JAPAN

来源：

FEBS LETTERS | 1990年 / 264卷 / 01期

关键词：

cDNA cloning; Gallus gallus domesticus; Glucagon; Glucagon-like peptide; mRNA; Preproglucagon;

D O I：

10.1016/0014-5793(90)80779-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cDNA clones coding for glucagon were isolated from a chicken pancreas cDNA library, and the nucleotide and amino acid sequences were determined. The amino acid sequence of chicken glucagon was HSQGTFTSDYSKYLDSRRAQDFVQWLMST, which was contained in the 151-amino acid long precursor, being preceded by a signal sequence and an amino-terminal peptide (NH2-peptide) and followed by an intervening peptide and a glucagon-like peptide I (GLP-I). Chicken preproglucagon, however, lacked GLP-II and intervening peptide II which have been shown to be contained in mammalian glucagon precursors. © 1990.

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页码：117 / 120

页数：4

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