PHYSICAL BASIS OF COGNITIVE ALTERATIONS IN ALZHEIMERS-DISEASE - SYNAPSE LOSS IS THE MAJOR CORRELATE OF COGNITIVE IMPAIRMENT

被引：3511

作者：

TERRY, RD ^{[1
]}

MASLIAH, E ^{[1
]}

SALMON, DP ^{[1
]}

BUTTERS, N ^{[1
]}

DETERESA, R ^{[1
]}

HILL, R ^{[1
]}

HANSEN, LA ^{[1
]}

KATZMAN, R ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,LA JOLLA,CA 92093

来源：

ANNALS OF NEUROLOGY | 1991年 / 30卷 / 04期

关键词：

D O I：

10.1002/ana.410300410

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present here both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of 15 patients with Alzheimer's disease and 9 neuropathologically normal subjects. The statistical data show only weak correlations between psychometric indices and plaques and tangles, but the density of neocortical synapses measured by a new immunocytochemical/densitometric technique reveals very powerful correlations with all three psychological assays. Multivariate analysis by stepwise regression produced a model including midfrontal and inferior parietal synapse density, plus inferior parietal plaque counts with a correlation coefficient of 0.96 for Mattis's Dementia Rating Scale. Plaque density contributed only 26% of that strength.

引用

页码：572 / 580

页数：9

共 50 条

[1]

APPEL SH, 1988, AGING BRAIN, P287

[2]

AMYLOID-BETA-A4 PROTEIN PATHOLOGY IS CENTRAL TO THE CAUSE OF ALZHEIMERS-DISEASE [J].