HIV-1 REVERSE-TRANSCRIPTASE INHIBITING ANTIBODY TITER IN SERUM - RELATION TO DISEASE PROGRESSION AND TO CORE-ANTIBODY LEVELS

被引:9
作者
NEUMULLER, M [1 ]
KARLSSON, A [1 ]
LENNERSTRAND, J [1 ]
KALLANDER, CFR [1 ]
SANDSTROM, E [1 ]
HOLMBERG, V [1 ]
GRONOWITZ, JS [1 ]
机构
[1] SODER SJUKHUSET,DEPT DERMATOVENEREOL,STOCKHOLM,SWEDEN
关键词
HIV ANTIBODIES; REVERSE TRANSCRIPTASE; PROGRESSION MARKER; HIV PROGRESSION;
D O I
10.1002/jmv.1890360410
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A new assay for detecting inhibition of reverse transcriptase activity (the RT-i REA) was developed. This assay was standardized for screening serum samples for reverse transcriptase inhibiting antibodies (RT-iAb). High specificity (100%) and sensitivity (> 98%) were achieved with samples from HIV-negative individuals and HIV-infected individuals. The RT-i REA was also used in a study of the titers of RT-iAb in serum samples obtained from 33 HIV-infected homosexual men. The results confirmed the relation between decreasing RT-iAb levels and progression to late stages of the disease. Furthermore, a falling RT-iAb titer was observed in 14 of 15 individuals experiencing periods of severe clinical symptoms attributed to HIV-activity. In 7 of the patients the decline in RT-iAb titer began prior to severe clinical symptoms. The fall in RT-iAb titer also correlated with a reduction in core Ab level. The core Ab level has previously been reported to be a disease progression marker with considerable prognostic value. However, whereas all patients were positive for RT-iAb, 8 of the 33 patients did not have detectable core Ab. The use of RT-iAb titer as a marker of disease progression is discussed.
引用
收藏
页码:283 / 291
页数:9
相关论文
共 21 条
[1]   CROSS-SECTIONAL STUDY OF REVERSE TRANSCRIPTASE-INHIBITING ANTIBODY AS A MARKER OF ACQUIRED IMMUNE-DEFICIENCY SYNDROME [J].
ADVANI, M ;
IMAGAWA, DT ;
LEE, MH ;
SANO, K ;
MORALES, F ;
MITSUYASU, RT ;
DETELS, R .
JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (07) :1453-1455
[2]   IMMUNOGENICITY OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) REVERSE-TRANSCRIPTASE - DETECTION OF HIGH-LEVELS OF ANTIBODIES TO HIV REVERSE-TRANSCRIPTASE IN SERA OF HOMOSEXUAL MEN [J].
CHATTERJEE, R ;
RINALDO, CR ;
GUPTA, P .
JOURNAL OF CLINICAL IMMUNOLOGY, 1987, 7 (03) :218-224
[3]  
DEWOLF F, 1988, J INFECT DIS, V158, P615, DOI 10.1093/infdis/158.3.615
[4]   THE PROGNOSTIC VALUE OF CELLULAR AND SEROLOGIC MARKERS IN INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 [J].
FAHEY, JL ;
TAYLOR, JMG ;
DETELS, R ;
HOFMANN, B ;
MELMED, R ;
NISHANIAN, P ;
GIORGI, JV .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (03) :166-172
[5]   IMMUNOLOGICAL AND SEROLOGICAL MARKERS PREDICTIVE OF PROGRESSION TO AIDS IN A COHORT OF HIV-INFECTED DRUG-USERS [J].
FERNANDEZCRUZ, E ;
DESCO, M ;
MONTES, MG ;
LONGO, N ;
GONZALEZ, B ;
ZABAY, JM .
AIDS, 1990, 4 (10) :987-994
[6]  
FRIEDLAND GH, 1991, J ACQ IMMUN DEF SYND, V4, P144
[7]   HIV-1 TESTING - PRODUCT DEVELOPMENT STRATEGIES [J].
GOTTFRIED, TD ;
URNOVITZ, HB .
TRENDS IN BIOTECHNOLOGY, 1990, 8 (02) :35-40
[8]   ANTIGENEMIA AND ANTIBODY-TITERS TO CORE AND ENVELOPE ANTIGENS IN AIDS, AIDS-RELATED COMPLEX, AND SUBCLINICAL HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].
GOUDSMIT, J ;
LANGE, JMA ;
PAUL, DA ;
DAWSON, GJ .
JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (03) :558-560
[9]  
GRONOWITZ JS, 1991, BIOTECHNOL APPL BIOC, V13, P127
[10]  
HOLLANDER M, 1973, NONPARAMETRIC STATIS