FALLOPIAN-TUBE SPERM PERFUSION USED IN A DONOR INSEMINATION PROGRAM

被引：13

作者：

KAHN, JA

VONDURING, V

SUNDE, A

MOLNE, K

机构：

[1] Departments of Obstetrics and Gynaecology, University of Trondheim

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 06期

关键词：

AID; FALLOPIAN TUBE SPERM PERFUSION (FSP); FROZEN SPERM;

D O I：

10.1093/oxfordjournals.humrep.a137741

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Ninety-six couples were enrolled in a programme of Fallopian tube sperm perfusion (FSP). FSP is a method combining ovarian stimulation, ovulation induction and intra-uterine insemination with a 4 ml volume of sperm suspension. Frozen/thawed donor semen was used in all cycles. A total of 196 treatment cycles were started and of these 172 were completed. Twenty cycles were cancelled because of maturation of too many follicles, a low ovarian response, or formation of ovarian cysts. Five of the women enrolled in the programme did not have any inseminations. Forty-eight pregnancies occurred (27.9% per cycle) among 45 women (49.5%). There were five spontaneous abortions and one ectopic pregnancy. Sixteen pregnancies are on-going (> 12 weeks) and 26 women have delivered (including two sets of triplets and one set of twins). The pregnancy rate declined from the first attempt (34. 1 %) to the fourth attempt (14.3%). The pregnancy rate was significantly higher in women with three to rive mature follicles compared to women with two or fewer mature follicles (P < 0.05). Cycles in which human chorionic gonadotrophin (HCG) was administered on day 11 or later had a higher pregnancy rate than cycles where HCG was administered on day 10 (P <0.01). There was no difference in pregnancy rates between insemination with 8 - 10 x 10(6) motile spermatozoa and insemination with > 30 x 10(6) motile spermatozoa. FSP used in a programme of artificial insemination by donor using frozen/thawed donor semen is relatively simple to perform and gives a high pregnancy rate per cycle.

引用

页码：806 / 812

页数：7

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