OLIGONUCLEOTIDES DERIVED FROM 5-(1-PROPYNYL)-2'-O-ALLYL-URIDINE AND 5-(1-PROPYNYL)-2'-O-ALLYL-CYTIDINE - SYNTHESIS AND RNA DUPLEX FORMATION

被引：52

作者：

FROEHLER, BC

JONES, RJ

CAO, XD

TERHORST, TJ

机构：

[1] Gilead Sciences Inc., Foster City, CA 94404

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)77476-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The protected nucleoside analogs of 5-(1-propynyl)-2'-O-allyl-uridine and 5-(1-propynyl)-2'-O-allyl-cytidine are described. Oligonucleotides containing this modification significantly enhance double-helix formation with single-strand RNA.

引用

页码：1003 / 1006

页数：4

共 16 条

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