TRANSCRIPTIONAL ACTIVATION OF DROSOPHILA HOMEOTIC GENES FROM DISTANT REGULATORY ELEMENTS

被引:140
作者
KENNISON, JA
机构
[1] Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda
关键词
D O I
10.1016/0168-9525(93)90227-9
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In Drosophila the genes responsible for specifying segment identity (the homeotic genes) are transcribed in complex patterns during development. Mutations that mimic loss of homeotic gene activity identify cis-acting DNA sequences and trans-acting proteins required for transcriptional activation. Some of the trans-acting proteins may facilitate interactions between cis-regulatory elements and the promoter by bringing together distant chromosomal elements.
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页码:75 / 79
页数:5
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