THE IRS-1 SIGNALING SYSTEM

被引:96
作者
WHITE, MF
机构
[1] Research Division, Harvard Medical School, Joslin Diabetes Center, Boston, MA 02215
关键词
D O I
10.1016/0959-437X(94)90090-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
IRS-1 is a principal substrate of the insulin receptor tyrosine kinase. It undergoes multi-site tyrosine phosphorylation and mediates the insulin signal by associating with various signaling molecules containing Src homology 2 domains. Interleukin-4 also stimulates IRS-1 phosphorylation, and it is suspected that a few more growth factors or cytokines will be added to form a select group of receptors that utilize the IRS-1 signaling pathway. More IRS-1-like adapter molecules, such as 4PS (IRS-2), may remain to be found.
引用
收藏
页码:47 / 54
页数:8
相关论文
共 44 条
  • [1] BINDING OF SH2 DOMAINS OF PHOSPHOLIPASE-C-GAMMA-1, GAP, AND SRC TO ACTIVATED GROWTH-FACTOR RECEPTORS
    ANDERSON, D
    KOCH, CA
    GREY, L
    ELLIS, C
    MORAN, MF
    PAWSON, T
    [J]. SCIENCE, 1990, 250 (4983) : 979 - 982
  • [2] HUMAN SKELETAL-MUSCLE INSULIN-RECEPTOR SUBSTRATE-1 - CHARACTERIZATION OF THE CDNA, GENE, AND CHROMOSOMAL LOCALIZATION
    ARAKI, E
    SUN, XJ
    HAAG, BL
    CHUANG, LM
    ZHANG, Y
    YANGFENG, TL
    WHITE, MF
    KAHN, CR
    [J]. DIABETES, 1993, 42 (07) : 1041 - 1054
  • [3] A SIMPLE, RAPID METHOD FOR THE PREPARATION OF PLASMA-MEMBRANES FROM LIVER
    ARMSTRONG, JM
    NEWMAN, JD
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 238 (02) : 619 - 628
  • [4] PHOSPHATIDYLINOSITOL 3'-KINASE IS ACTIVATED BY ASSOCIATION WITH IRS-1 DURING INSULIN STIMULATION
    BACKER, JM
    MYERS, MG
    SHOELSON, SE
    CHIN, DJ
    SUN, XJ
    MIRALPEIX, M
    HU, P
    MARGOLIS, B
    SKOLNIK, EY
    SCHLESSINGER, J
    WHITE, MF
    [J]. EMBO JOURNAL, 1992, 11 (09) : 3469 - 3479
  • [5] BACKER JM, 1993, J BIOL CHEM, V268, P8204
  • [6] ONCOGENES AND SIGNAL TRANSDUCTION
    CANTLEY, LC
    AUGER, KR
    CARPENTER, C
    DUCKWORTH, B
    GRAZIANI, A
    KAPELLER, R
    SOLTOFF, S
    [J]. CELL, 1991, 64 (02) : 281 - 302
  • [7] INSULIN-STIMULATED OOCYTE MATURATION REQUIRES INSULIN-RECEPTOR SUBSTRATE-1 AND INTERACTION WITH THE SH2 DOMAINS OF PHOSPHATIDYLINOSITOL 3-KINASE
    CHUANG, LM
    MYERS, MG
    BACKER, JM
    SHOELSON, SE
    WHITE, MF
    BIRNBAUM, MJ
    KAHN, CR
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (11) : 6653 - 6660
  • [8] INSULIN-RECEPTOR SUBSTRATE-1 MEDIATES INSULIN AND INSULIN-LIKE GROWTH FACTOR-I-STIMULATED MATURATION OF XENOPUS-OOCYTES
    CHUANG, LM
    MYERS, MG
    SEIDNER, GA
    BIRNBAUM, MJ
    WHITE, MF
    KAHN, CR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) : 5172 - 5175
  • [9] ASSOCIATION OF SOS RAS EXCHANGE PROTEIN WITH GRB2 IS IMPLICATED IN TYROSINE KINASE SIGNAL TRANSDUCTION AND TRANSFORMATION
    EGAN, SE
    GIDDINGS, BW
    BROOKS, MW
    BUDAY, L
    SIZELAND, AM
    WEINBERG, RA
    [J]. NATURE, 1993, 363 (6424) : 45 - 51
  • [10] IDENTIFICATION OF A HUMAN SRC HOMOLOGY 2-CONTAINING PROTEIN-TYROSINE-PHOSPHATASE - A PUTATIVE HOMOLOG OF DROSOPHILA CORKSCREW
    FREEMAN, RM
    PLUTZKY, J
    NEEL, BG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (23) : 11239 - 11243