A NEW ANTIBIOTIC, CYPEMYCIN - TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

被引：42

作者：

KOMIYAMA, K

OTOGURO, K

SEGAWA, T

SHIOMI, K

YANG, H

TAKAHASHI, Y

HAYASHI, M

OTANI, T

OMURA, S

机构：

[1] KITASATO UNIV,KITASATO INST,5-9-1 SHIROKANE,MINATO KU,TOKYO 108,JAPAN

[2] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

[3] TAIHO PHARMACEUT CO LTD,TOKUSHIMA 77101,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 11期

关键词：

D O I：

10.7164/antibiotics.46.1666

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new peptide antibiotic, cypemycin, with a molecular weight of 2,097 (M + H), was isolated from the culture broth of Streptomyces sp. OH-4156. The antibiotic possesses cytocidal activity against P388 leukemia cells in vitro at a concentration of 1.3 mug/ml (IC50 values), and the antibiotic showed antimicrobial activities against Micrococcus luteus (MIC, 0.2 mug/ml).

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页码：1666 / 1671

页数：6

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