MODULATORY EFFECT OF PLASMINOGEN ON NMDA-INDUCED INCREASE IN INTRACELLULAR FREE CALCIUM-CONCENTRATION IN RAT CULTURED HIPPOCAMPAL-NEURONS

被引：25

作者：

INOUE, K ^{[1
]}

KOIZUMI, S ^{[1
]}

NAKAJIMA, K ^{[1
]}

HAMANOUE, M ^{[1
]}

KOHSAKA, S ^{[1
]}

机构：

[1] NATL INST NEUROSCI,DEPT NEUROCHEM,KODAIRA,TOKYO 187,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 179卷 / 1-2期

关键词：

PLASMINOGEN; NMDA; HIPPOCAMPUS; CA2+;

D O I：

10.1016/0304-3940(94)90941-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of plasminogen on the intracellular Ca2+ concentration ([Ca](i)) was examined in cultured rat hippocampal neurons. Plasminogen (100 nM) did not increase [Ca](i) in the presence of tetrodotoxin (TTX, 3 mu M) but increased [Ca](i) in the absence of TTX. In all the cells which responded to plasminogen (100 nM), NMDA (5 mu M) also increased [Ca](i) in the presence of TTX. Furthermore, plasminogen (100 nM) enhanced the NMDA-evoked [Ca](i) increase, and the potentiation by plasminogen was blocked by an NMDA receptor blocker, 2-amino-phosphonovalerate (APV). These data suggest that plasminogen enhances glutamate-evoked [Ca](i) increase through modulation of NMDA receptor in hippocampal neurons.

引用

页码：87 / 90

页数：4

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