A DOUBLE-BLIND-STUDY OF DEFLAZACORT AND PREDNISONE IN PATIENTS WITH CHRONIC INFLAMMATORY DISORDERS

被引：70

作者：

GRAY, RES

DOHERTY, SM

GALLOWAY, J

COULTON, L

DEBROE, M

KANIS, JA

机构：

[1] UNIV SHEFFIELD, SCH MED, DEPT HUMAN METAB & CLIN BIOCHEM, SHEFFIELD S10 2TN, S YORKSHIRE, ENGLAND

[2] HULL ROYAL INFIRM, DEPT RHEUMATOL, Kingston Upon Hull HU3 2JZ, N HUMBERSIDE, ENGLAND

[3] UNIV INSTELLING ANTWERP, DEPT NEPHROL, B-2610 Antwerp, BELGIUM

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 03期

关键词：

D O I：

10.1002/art.1780340306

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Deflazacort and prednisone were given to 26 patients with rheumatoid arthritis, polymyalgia rheumatica, or other chronic inflammatory diseases, in a double-blind study. Deflazacort rapidly and effectively suppressed disease activity in a manner supporting its assumed therapeutic potency of 83% that of prednisone. Prednisone induced a rapid increase in the level of daily calcium excretion that was not evident with deflazacort. Cortisol secretion was acutely inhibited by prednisone, but not by deflazacort. Neither corticosteroid had a significant effect on glucose metabolism, at the doses studied. Treatment with deflazacort may be an effective alternative to prednisone treatment, with fewer adverse effects on levels of calcium and cortisol, in patients with severe inflammatory conditions warranting the use of glucocorticoids.

引用

页码：287 / 295

页数：9

共 42 条

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