HISTIDINE-DECARBOXYLASE GENE-EXPRESSION IN RAT FUNDUS IS REGULATED BY GASTRIN

被引：110

作者：

DIMALINE, R

SANDVIK, AK

机构：

[1] MRC Secretory Control Research Group, Department of Physiology, University of Liverpool, Liverpool

来源：

FEBS LETTERS | 1991年 / 281卷 / 1-2期

关键词：

HISTIDINE DECARBOXYLASE; GASTRIN; PCR; MESSENGER RNA; GENE EXPRESSION; RAT FUNDUS;

D O I：

10.1016/0014-5793(91)80348-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The conversion of histidine to histamine by histidine decarboxylase (HDC) is of central importance in the control of vertebrate acid secretion. We have used PCR-generated probes to study the regulation of HDC gene expression in rat fundic mucosa. When circulating gastrin levels were lowered by fasting or elevated by treatment with omeprazole, there were parallel changes in HDC mRNA abundance. However, when animals with elevated gastrin levels were concurrently treated with the gastrin/CCK-B receptor antagonist PD 134308, HDC mRNA levels were not increased. These data are consistent with the hypothesis that HDC gene expression is regulated by gastrin, over the physiological range of circulating hormone concentrations.

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页码：20 / 22

页数：3

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