EFFECTS OF FISH OIL RICH IN EICOSAPENTAENOIC ACID ON FOCAL GLOMERULOSCLEROSIS OF ADRIAMYCIN-INDUCED NEPHROPATHY IN RATS

被引：6

作者：

WASHIO, M

NANISHI, F

ONOYAMA, K

OKUDA, S

FUJISHIMA, M

机构：

[1] Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka

来源：

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1993年 / 53卷 / 01期

关键词：

D O I：

10.1016/S0011-393X(05)80153-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of fish oil rich in eicosapentaenoic acid (EPA) and those of purified EPA on the progression of focal glomerulosclerosis were investigated in adriamycin (ADR)-injected rats, a model of progressive chronic renal failure. Fish oil and purified EPA were administered through a gastric tube 1 week after the ADR injections. When compared with the control rats (ADR-CON), total cholesterol was significantly lower in the rats receiving fish oil (ADR-FO) or purified EPA (ADR-EPA) at week 8 (P < 0.05). At week 16, urinary protein excretion, serum creatinine elevation, and glomerulosclerosis were ameliorated in the ADR-FO and ADR-EPA groups but not in the ADR-CON group. Fish oil and purified EPA appear to be potent agents in preventing focal glomerulosclerosis.

引用

页码：35 / 41

页数：7

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