A COMPARATIVE-STUDY OF SINGLE-DOSE GROWTH-HORMONE THERAPY AS AN ADJUVANT TO GONADOTROPIN TREATMENT FOR OVULATION INDUCTION

被引：44

作者：

HOMBURG, R

WEST, C

TORRESANI, T

JACOBS, HS

机构：

[1] UNIV COLL & MIDDLESEX SCH MED,MIDDLESEX HOSP,COBBOLD LABS,MORTIMER ST,LONDON WIN 8AA,ENGLAND

[2] KINDERSPITAL,PROT HORMON LAB,CH-8032 ZURICH,SWITZERLAND

来源：

CLINICAL ENDOCRINOLOGY | 1990年 / 32卷 / 06期

关键词：

D O I：

10.1111/j.1365-2265.1990.tb00925.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One intramuscular injection of biosynthetic human growth hormone (24 IU), administered on the first day of gonadotrophin treatment for ovulation induction, significantly augmented the ovarian response to gonadotrophic stimulation in seven patients. Compared with a protocol involving six injections of 24 IU of GH given on alternate days to the same patients, the smaller dose had an intermediate but highly significant effect in reducing the amount, duration of treatment and daily effective dose of hMG needed to induce ovulation. The difference between the effect of the one‐dose and six‐dose protocols was small. The action of growth hormone on the human ovary, probably mediated by insulin‐like growth factor‐1 (IGF‐1), appears effective in enhancing the response to gonadotrophin therapy even when given in a single dose. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：781 / 785

页数：5

共 12 条

[1] SOMATOMEDIN-C SYNERGIZES WITH FOLLICLE-STIMULATING-HORMONE IN THE ACQUISITION OF PROGESTIN BIOSYNTHETIC CAPACITY BY CULTURED RAT GRANULOSA-CELLS [J].