SQUAMOUS-CELL CARCINOMA ANTIGEN IS A NEW MEMBER OF THE SERINE PROTEASE INHIBITORS

被引：195

作者：

SUMINAMI, Y

KISHI, F

SEKIGUCHI, K

KATO, H

机构：

[1] ONODA MUNICIPAL HOSP,DIV OBSTET & GYNECOL,ONODA,YAMAGUCHI 756,JAPAN

[2] YAMAGUCHI UNIV,SCH MED,DEPT OBSTET & GYNECOL,UBE,YAMAGUCHI 755,JAPAN

[3] DAINABOT CO LTD,MINATO KU,TOKYO 105,JAPAN

[4] YAMAGUCHI UNIV,SCH MED,DEPT PEDIAT,UBE,YAMAGUCHI 755,JAPAN

[5] STANFORD UNIV,MED CTR,SCH MED,DEPT MICROBIOL & IMMUNOL,STANFORD,CA 94305

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 181卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81380-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned cDNA of squamous cell carcinoma antigen. Sequence analysis of the complete 1711 basepairs SCC antigen cDNA revealed that it coded 390 amino acids and no typical signal sequence in the NH2-terminus. Northern blot analysis of human squamous cell poly (A)+ RNA using this cDNA insert as the probe showed a single RNA species of about 1.7 kilobases. The cDNA was expressed in Escherichia coli and the product was detected by immunological methods using antibodies against SCC antigen, indicating that this cDNA encodes the entire SCC antigen sequence. The amino acid homology search revealed that SCC antigen was a member of the serine protease inhibitors family. © 1991 Academic Press, Inc.

引用

页码：51 / 58

页数：8

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