UPTAKE AND BIOTRANSFORMATION OF ALIFLURANE (1-CHLORO-2-METHOXY-1,2,3,3-TETRAFLUOROCYCLO-PROPANE, COMPOUND 26-P) IN MAN

被引：4

作者：

HOLADAY, DA

JARDINES, MC

GREENWOOD, WH

机构：

来源：

ANESTHESIOLOGY | 1979年 / 51卷 / 06期

关键词：

D O I：

10.1097/00000542-197912000-00014

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The biotransformation of aliflurane was studied in ten healthy young male volunteers. It appears to be highly resistant to biotransformation in man. The maximum excretion of fluoride and organic fluorine occurred during the first 24 hours following exposure.

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页码：548 / 550

页数：3

相关论文

共 11 条

[1] BIOTRANSFORMATION AND HEPATOTOXICITY OF HALOTHANE [J].

BROWN, BR ;

SIPES, IG .

BIOCHEMICAL PHARMACOLOGY, 1977, 26 (22) :2091-2094

[2] DIFFERENCES IN BIOTRANSFORMATION OF HALOTHANE IN MAN [J].

CASCORBI, HF ;

BLAKE, DA ;

HELRICH, M .

ANESTHESIOLOGY, 1970, 32 (02) :119-&

[3] BIOTRANSFORMATION OF ETHRANE IN MAN [J].

CHASE, RE ;

HOLADAY, DA ;

FISEROVA.V ;

SAIDMAN, LJ ;

MACK, FE .

ANESTHESIOLOGY, 1971, 35 (03) :262-&

[4] METHOXYFLURANE NEPHROTOXICITY - STUDY OF DOSE-RESPONSE IN MAN [J].

COUSINS, MJ ;

MAZZE, RI .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1973, 225 (13) :1611-1616

[5] A SIMPLIFIED METHOD FOR MEASUREMENT OF VOLATILE ANESTHETICS IN BLOOD BY GAS CHROMATOGRAPHY [J].

FINK, BR ;

MORIKAWA, K .

ANESTHESIOLOGY, 1970, 32 (05) :451-&

[6] CHANGES OF FLUORIDE CONTENT IN BONE - INDEX OF DRUG DEFLUORINATION IN-VIVO [J].

FISEROVA.V .

ANESTHESIOLOGY, 1973, 38 (04) :345-351

[7] BIOTRANSFORMATION OF FLUROXENE IN MAN [J].

GION, H ;

YOSHIMURA, N ;

HOLADAY, DA ;

FISEROVA.V ;

CHASE, RE .

ANESTHESIOLOGY, 1974, 40 (06) :553-562

[8]

MUNSON ES, 1979, ANESTHESIOLOGY, V71, P545

[9] HALOTHANE BIOTRANSFORMATION IN MAN - A QUANTITATIVE STUDY [J].

REHDER, K ;

FORBES, J ;

ALTER, H ;

HESSLER, O ;

STIER, A .

ANESTHESIOLOGY, 1967, 28 (04) :711-&

[10] METABOLISM OF METHOXYFLURANE IN MAN [J].

YOSHIMURA, N ;

HOLADAY, DA ;

FISEROVABERGEROVA, V .

ANESTHESIOLOGY, 1976, 44 (05) :372-379