BIS(HYDROPEROXY)NAPHTHALDIIMIDE AS A PHOTO-FENTON REAGENT - SEQUENCE-SPECIFIC PHOTOCLEAVAGE OF DNA

被引：87

作者：

MATSUGO, S

KAWANISHI, S

YAMAMOTO, K

SUGIYAMA, H

MATSUURA, T

SAITO, I

机构：

[1] KYOTO UNIV,FAC ENGN,DEPT SYNTHET CHEM,KYOTO 606,JAPAN

[2] KOBE UNIV MERCANTILE MARINE,KOBE 658,JAPAN

[3] KYOTO UNIV,FAC MED,DEPT PUBL HLTH,KYOTO 606,JAPAN

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 10期

关键词：

D O I：

10.1002/anie.199113511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Light of wavelength 360 nm is sufficient to form hydroxyl radicals from the bis-(hydroperoxide) 1 (R = CH2CH(OMe)OOH). Thus 1 is an attractive photo-Fenton reagent for biological applications. First experiments showed that 1 can cut double-stranded DNA selectively at the 5' site of 5'-GG-3' sequences.

引用

页码：1351 / 1353

页数：3

共 27 条

[1] BIELSKI BH, 1977, FREE RADIC BIOL, V1, P1
[2] BASE-SPECIFIC PHOTOCLEAVAGE OF DNA INDUCED BY NANOSECOND UV PULSED LASER-RADIATION OR METHYLENE-BLUE SENSITIZATION
BLAU, W
CROKE, DT
KELLY, JM
MCCONNELL, DJ
OHUIGIN, C
VANDERPUTTEN, WJM
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (10) : 751 - 752
[3] DAVIES KJA, 1987, J BIOL CHEM, V26, P9895
[4] MODIFICATION OF BASES IN DNA BY COPPER ION-1,10-PHENANTHROLINE COMPLEXES
DIZDAROGLU, M
ARUOMA, OI
HALLIWELL, B
[J]. BIOCHEMISTRY, 1990, 29 (36) : 8447 - 8451
[5] FINKELSTEIN E, 1980, ARCH BIOCHEM BIOPHYS, V20, P1
[6] BASE-SPECIFIC REACTIONS USEFUL FOR DNA SEQUENCING - METHYLENE-BLUE - SENSITIZED PHOTO-OXIDATION OF GUANINE AND OSMIUM TETRAOXIDE MODIFICATION OF THYMINE
FRIEDMANN, T
BROWN, DM
[J]. NUCLEIC ACIDS RESEARCH, 1978, 5 (02) : 615 - 622
[7] OXYGEN-TOXICITY, OXYGEN RADICALS, TRANSITION-METALS AND DISEASE
HALLIWELL, B
GUTTERIDGE, JMC
[J]. BIOCHEMICAL JOURNAL, 1984, 219 (01) : 1 - 14
[8] HERZBERG RP, 1984, BIOCHEMISTRY-US, V23, P3934
[9] Horspool W. M, 1986, PHOTOCHEMISTRY ORGAN, P61
[10] A NEW STRATEGY FOR SELECTIVE PROTEIN CLEAVAGE
HOYER, D
CHO, H
SCHULTZ, PG
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (08) : 3249 - 3250

← 1 2 3 →