SUPPRESSOR T-CELL LEVELS ARE UNRELIABLE INDICATORS OF THE IMPAIRED IMMUNE-RESPONSE FOLLOWING THERMAL-INJURY

被引:3
作者
GOUGH, DB [1 ]
JORDAN, A [1 ]
COLLINS, K [1 ]
MANNICK, JA [1 ]
RODRICK, ML [1 ]
机构
[1] HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,DEPT SURG, 75 FRANCIS ST, BOSTON, MA 02115 USA
来源
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE | 1992年 / 32卷 / 06期
关键词
D O I
10.1097/00005373-199206000-00001
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The presence of increased levels of suppressor T cells after thermal injury and their relevance remain controversial. It is unclear whether suppressor T cells are the cause or result of sepsis complicating thermal injury. Spleen cells from a standardized murine burn model and sham burn controls were studied and the relationship between the levels of suppressor cytotoxic T cells (CD8, Lyt-2+), helper T cells (CD4, L3T4+), response to concanavalin A (ConA) and to phytohemagglutinin (PHA) and interleukin-2 (IL-2) production was examined. Mortality following infection via cecal ligation and puncture (CLP) of matched controls was also studied. At day 7 postburn, mean ConA (70 +/-12% of control) and PHA response (58% +/- 5.2% of controls) and IL-2 production (43% +/- 5.4%) were significantly less than sham burn values (100%; p < 0.05). However, the mean percentage of cells staining with anti-Lyt-2 and anti-L3T4 (9.1 +/- 0.59 and 13.9 +/- 0.65) was similar to the mean percentage in sham burn animals (9.4 +/- 0.65 and 16.6 +/- 1.1). Furthermore, no significant differences were observed between burned mice and controls in helper (17.3 % +/- 1.8% burn vs. 21.2% +/- 1.7% sham) or suppressor cell levels (7.8% +/- 1.2% burn vs. 8.6% +/- 0.7% sham) or helper-suppressor ratios on day 10 postburn. Mortality of 20 litter-matched controls subjected to CLP on day 10 postburn was 90%, which was significantly greater than the sham burn mortality of 20%. We conclude that phenotypic assessment of splenocytes using monoclonal antibodies Lyt-2 and L3T4 as markers of suppressor and helper T cells is an unreliable indicator of impaired immune response and susceptibility to sepsis following thermal injury.
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页码:677 / 682
页数:6
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