EFFECTS OF VASOACTIVE INTESTINAL POLYPEPTIDE ON ISOLATED RAT URINARY-BLADDER SMOOTH-MUSCLE

被引:16
作者
EROL, K
ULAK, G
DONMEZ, T
CINGI, MI
ALPAN, RS
OZDEMIR, M
机构
[1] Department of Pharmacology, University of Anadolu, School of Medicine, Eskişehir
[2] Department of Urology, University of Anadolu, School of Medicine, Eskişehir
[3] Department of Pharmacology, University of Dicle, School of Medicine, Diyarbakir
关键词
VASOACTIVE INTESTINAL POLYPEPTIDE; RAT URINARY BLADDER;
D O I
10.1159/000282414
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
The effect of vasoactive intestinal polypeptide (VIP) on the contractile activity of the urinary bladder was investigated in the rat. VIP caused a weak contraction and a small potentiation of carbachol- and acetylcholine-induced contractions. The present results may provide the evidence that VIP could be a modulator in the urinary bladder.
引用
收藏
页码:151 / 153
页数:3
相关论文
共 19 条
[1]
Said S.I., Mutt V., Polypeptide with broad biological activity: Isolation from small intestine, Science, 169, pp. 1217-1218, (1970)
[2]
Said S.I., Rosenberg R.W., Vasoactive intestinal polypeptide: Abundant immunoreactivity in neural cell lines and normal nervous tissue, Science, 192, pp. 907-908, (1976)
[3]
Larsson L.I., Occurrence of nerves contained vasoactive intestinal polypeptide immunoreactivity in male genital tract, Life Sci, 21, pp. 503-508, (1977)
[4]
Larsson L.I., Fahrenkrug J., de Muckadell Schaffalitzky O.B., Vasoactive intestinal polypeptide occurs in nerves of the male genitourinary tract, Science, 197, pp. 1374-1375, (1977)
[5]
Goyal R.K., Rattan S., Said S.I., VIP as a possible neurotransmitter of noncholinergic nonadrenergic inhibitory neurones, Nature, 288, pp. 378-380, (1980)
[6]
Piper P.J., Said S.I., Vane J.R., Effects on smooth muscle preparations of unidentified vasoactive peptides from intestine and lung, Nature, 225, pp. 1144-1146, (1976)
[7]
Hand M.J., Laravuso R.B., Will A.J., Relaxation of isolated guinea pig trachea, bronchi and pulmonary arteries produced by vasoactive intestinal peptide (VIP), Eur J Pharmacol, 98, pp. 279-284, (1984)
[8]
Krejs G.J., Barkley R.M., Read N.W., Fordtran J.S., Intestinal secretion induced by vasoactive intestinal polypeptide, J Clin Invest, 78, pp. 1337-1345, (1977)
[9]
Eklund S., Jodal M., Lundgren O., Sjoqvist A., Effects of vasoactive intestinal polypeptide on blood flow, motility and fluid transport in the gastrointestinal tract of the cat, Acta Physiol Scand, 105, pp. 461-468, (1979)
[10]
Venugopalan C.S., Said S.I., Drazen J.M., Effects of vasoactive intestinal peptide (VIP), isoproterenol (ISO) on the guinea pig tracheal pouch relaxation induced by vagal and sympathetic trunk stimulation, Physiologist, 24, (1981)