NEW ANTIVIRAL ANTIBIOTICS, KISTAMICIN-A AND KISTAMICIN-B .2. STRUCTURE DETERMINATION

被引：33

作者：

NARUSE, N ^{[1
]}

OKA, M ^{[1
]}

KONISHI, M ^{[1
]}

OKI, T ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB RES INST,MEGURO KU,TOKYO 153,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 12期

关键词：

D O I：

10.7164/antibiotics.46.1812

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of antiviral antibiotics kistamicins A and B have been determined by a combination of chemical degradation and spectral analysis. They are commonly composed of D-tyrosine, 3,5-dihydrophenylglycine, a biphenyl ether bis-amino acid, and a diphenyl substituted indole tris-amino acid, forming a tricyclic ring structure. Kistamicin B possessed a phenethylamide at the amino terminal of kistamicin A. They are structurally related to the nuclei of the vancomycin group antibiotics particularly to antibiotic complestatin.

引用

页码：1812 / 1818

页数：7

共 7 条

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