INCREASED PLATELET SEROTONIN CONTENT AND HYPERSECRETION FROM DENSE AND ALPHA-GRANULES IN-VITRO IN TENSION-TYPE HEADACHE

被引：13

作者：

DANDREA, G ^{[1
]}

HASSELMARK, L ^{[1
]}

ALECCI, M ^{[1
]}

PERINI, F ^{[1
]}

WELCH, KMA ^{[1
]}

机构：

[1] HENRY FORD HOSP,DEPT NEUROL,DETROIT,MI 48202

来源：

CEPHALALGIA | 1993年 / 13卷 / 05期

关键词：

PLATELET AGGREGATION; PLATELET FACTOR-IV (PF4); PLATELET SECRETION; SEROTONIN; TENSION HEADACHE;

D O I：

10.1046/j.1468-2982.1993.1305349.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated platelet aggregation and secretion from dense and alpha-granules in vitro in 28 tension-type headache (TH) patients and 26 healthy controls. We also measured basal platelet serotonin levels. Platelet aggregation was normal in TH, but the secretion of serotonin and platelet factor 4 (PF4) was significantly increased in response to 0.5 and 2.0 mug/ml collagen and to 1.0 mumol/l PAF. The basal platelet serotonin levels were also higher in patients than in controls. The mechanisms of platelet hypersecretion remain to be determined, but the increased secretion of serotonin is probably in part related to the increased basal levels. The increased platelet serotonin in TH patients may reflect an enhanced serotonin turnover.

引用

页码：349 / 353

页数：5

共 18 条

[1] PLASMA SEROTONIN IN PATIENTS WITH CHRONIC TENSION HEADACHES [J].