EFFECT OF POLYANETHOLESULFONIC ACID AND XYLAN SULFATE ON ANTITHROMBIN-III ACTIVITY

被引：22

作者：

KINDNESS, G

WILLIAMSON, FB

LONG, WF

机构：

[1] Department of Biochemistry, University of Aberdeen, Marischal College, Aberdeen

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91516-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Both polyanetholesulphonic acid and xylan sulphate prolonged the partial thromboplastin clotting time of plasma. The anticoagulant effect of both compounds was reduced following pre-incubation of plasma with antiserum specific for antithrombin III. Polyanetholesulphonic acid was more effective than xylan sulphate in inhibiting thrombin-initiated clotting of plasma, and potentiated antithrombin III inhibition of both thrombin and Xa. Xylan sulphate was more effective in potentiating antithrombin III inhibition of Xa than of thrombin. These differential effects of xylan sulphate on different blood serine proteases are discussed in terms of the antithrombin III-mediated anticoagulant activity of heparin. © 1979.

引用

页码：1062 / 1068

页数：7

共 12 条

[1] ANTITHROMBIN-III AND HEPARIN [J].