EFFECTS OF NOISE ON HIGH-AFFINITY CHOLINE UPTAKE IN THE FRONTAL-CORTEX AND HIPPOCAMPUS OF THE RAT ARE BLOCKED BY INTRACEREBROVENTRICULAR INJECTION OF CORTICOTROPIN-RELEASING FACTOR ANTAGONIST

被引:14
作者
LAI, H [1 ]
CARINO, MA [1 ]
机构
[1] UNIV WASHINGTON,CTR BIOENGN,SCH MED,SEATTLE,WA 98195
关键词
Corticotropin-releasing factor; Endogenous opioid; Frontal cortex; High-affinity choline uptake; Hippocampus; Noise; Stress;
D O I
10.1016/0006-8993(90)91159-E
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Acute exposure (20 min) to loud noise (100 dB) decreased sodium-dependent high-affinity choline uptake activities in the frontal cortex and hippocampus of the rat. These effects were blocked by intracerebroventricular (i.c.v.) administration of the cotricotropin-releasing factor (CRF) antagonist α-helical-CRF9-41 (α-HCRF) immediately before noise exposure. Intracerebroventricular injection of CRF (1 μg) also decreased high-affinity choline uptake in the frontal cortex and the hippocampus of the rat, and these effects of CRF could be blocked by pretreating the animal with the narcotic antagonist naltrexone (1 mg/kg, i.p.). These results indicate that the effects of noise on central cholinergic systems are mediated by CRF and suggest a stressor-CRF-endogenous opioid-acetylcholine sequence of effects in the brain. © 1990.
引用
收藏
页码:354 / 358
页数:5
相关论文
共 35 条
[1]   EFFECT OF INESCAPABLE SHOCK ON SUBSEQUENT ESCAPE PERFORMANCE - CATECHOLAMINERGIC AND CHOLINERGIC MEDIATION OF RESPONSE INITIATION AND MAINTENANCE [J].
ANISMAN, H ;
REMINGTON, G ;
SKLAR, LS .
PSYCHOPHARMACOLOGY, 1979, 61 (02) :107-124
[2]   CORTICOTROPIN-RELEASING FACTOR ELICITS NALOXONE SENSITIVE STRESS-LIKE ALTERATIONS IN EXPLORATORY-BEHAVIOR IN MICE [J].
BERRIDGE, CW ;
DUNN, AJ .
REGULATORY PEPTIDES, 1986, 16 (01) :83-93
[3]  
CHAPPELL PB, 1986, J NEUROSCI, V6, P2908
[4]   COMPARISON OF PEPTIDE RELEASE FROM FETAL-RAT HYPOTHALAMIC NEURONS CULTURED IN DEFINED MEDIA AND SERUM-CONTAINING MEDIA [J].
CLARKE, MJO ;
GILLIES, GE .
JOURNAL OF ENDOCRINOLOGY, 1988, 116 (03) :349-356
[5]   BEHAVIORAL INVESTIGATION OF THE COEXISTENCE OF SUBSTANCE-P, CORTICOTROPIN RELEASING-FACTOR, AND ACETYLCHOLINESTERASE IN LATERAL DORSAL TEGMENTAL NEURONS PROJECTING TO THE MEDIAL FRONTAL-CORTEX OF THE RAT [J].
CRAWLEY, JN ;
OLSCHOWKA, JA ;
DIZ, DI ;
JACOBOWITZ, DM .
PEPTIDES, 1985, 6 (05) :891-901
[6]  
CUMMINGS S, 1983, J NEUROSCI, V3, P1355
[7]  
DESOUZA EB, 1985, J NEUROSCI, V5, P3189
[8]   INCREASED CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN RAT CEREBRAL-CORTEX FOLLOWING CHRONIC ATROPINE TREATMENT [J].
DESOUZA, EB ;
BATTAGLIA, G .
BRAIN RESEARCH, 1986, 397 (02) :401-404
[9]   EFFECTS OF STRESS ON MUSCARINIC MECHANISMS [J].
DILSAVER, SC .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1988, 12 (01) :23-28
[10]   ACETYLCHOLINE AND ITS ENZYMES IN SOME BRAIN-AREAS OF THE RAT UNDER STRESS [J].
FATRANSKA, M ;
BUDAI, D ;
OPRSALOVA, Z ;
KVETNANSKY, R .
BRAIN RESEARCH, 1987, 424 (01) :109-114