THE SYNTHESIS AND CCK RECEPTOR AFFINITIES OF SELECTED CARBOXYLIC-ACID MIMICS OF CL-988 - A POTENT AND SELECTIVE CCK-B ANTAGONIST

被引：5

作者：

DRYSDALE, MJ

PRITCHARD, MC

HORWELL, DC

机构：

[1] Parke Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge, CB22 2QB, Hills Rd

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80652-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Syntheses of selected acid mimics of the CCK-B selective receptor antagonist CI-988 (1) are described. The relationship between pK(a) and CCK-B binding affinities of these compounds are discussed.

引用

页码：45 / 48

页数：4

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