IDENTIFICATION OF A HIGH-RISK SUBGROUP OF GRADE-1 TRANSITIONAL CELL-CARCINOMA USING IMAGE-ANALYSIS BASED DEOXYRIBONUCLEIC-ACID PLOIDY ANALYSIS OF TUMOR-TISSUE

被引：53

作者：

HEMSTREET, GP

ROLLINS, S

JONES, P

RAO, JY

HURST, RE

BONNER, RB

HEWETT, T

SMITH, BG

机构：

[1] UNIV OKLAHOMA,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,OKLAHOMA CITY,OK 73190

[2] UNIV OKLAHOMA,HLTH SCI CTR,DEPT BIOCHEM,OKLAHOMA CITY,OK 73190

[3] UNIV OKLAHOMA,HLTH SCI CTR,DEPT MOLEC BIOL,OKLAHOMA CITY,OK 73190

[4] UNIV OKLAHOMA,HLTH SCI CTR,DEPT ENVIRONM HLTH,OKLAHOMA CITY,OK 73190

[5] BAPTIST MED CTR,DEPT PATHOL,OKLAHOMA CITY,OK

[6] BAPTIST MED CTR,DEPT UROL,OKLAHOMA CITY,OK

来源：

JOURNAL OF UROLOGY | 1991年 / 146卷 / 06期

关键词：

CARCINOMA; TRANSITIONAL CELL; BLADDER NEOPLASMS; DNA; NEOPLASM; FLOW CYTOMETRY;

D O I：

10.1016/S0022-5347(17)38157-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The use of deoxyribonucleic acid (DNA) cytometry to identify a subset of patients with grade 1, stage Ta or T1 transitional cell carcinoma at high risk for death or recurrence was investigated in a retrospective study using paraffin blocks from 88 low grade transitional cell carcinomas of the bladder with an absorptiometric video-based image analysis system. Tumors were evaluated for ploidy (70 diploid, 16 aneuploid and 2 tetraploid) and the presence of cells with greater than 5C DNA. Survival analysis of 62 patients with adequate followup (15 to 20 years) showed that 43 of 62 (69%) suffered recurrences and 13 (21%) died of bladder cancer. The single most important predictors of death and recurrence were stem line aneuploidy and the presence of cells with greater than 5C DNA, respectively.

引用

页码：1525 / 1529

页数：5

共 30 条

[1] CYTOPHOTOMETRY [J].