EVIDENCE FOR UP-REGULATION OF GALANIN SYNTHESIS IN RAT GLIAL-CELLS INVIVO AFTER COLCHICINE TREATMENT

被引：20

作者：

XU, Z

CORTES, R

VILLAR, M

MORINO, P

CASTEL, MN

HOKFELT, T

机构：

[1] Department of Histology and Neurobiology, Karolinska Institute, Stockholm

来源：

NEUROSCIENCE LETTERS | 1992年 / 145卷 / 02期

关键词：

NEUROPEPTIDE; BRAIN; LESION; PLASTICITY; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0304-3940(92)90018-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization of galanin (GAL) and GAL mRNA was studied in rat brain after colchicine or vinblastine treatment using in situ hybridization and immunohistochemistry. GAL-like immunoreactivity was found in glial cells, presumably activated microglia, in the cortex, caudate nucleus and septum, mainly on the injection side. GAL mRNA expression was found in small cells in the same areas with an overlapping distribution, including the adjacent white matter. The results suggest that the glial cells initiate synthesis of the peptide GAL in response to intraventricular injection of high doses of the 2 mitosis inhibitors.

引用

页码：185 / 188

页数：4

共 22 条

[1]

BARRES BA, 1991, J NEUROSCI, V11, P3685

[2]

COONS AH, 1958, GENERAL CYTOCHEMICAL, P399

[3] EFFECTS OF CENTRAL-NERVOUS-SYSTEM LESIONS ON THE EXPRESSION OF GALANIN - A COMPARATIVE INSITU HYBRIDIZATION AND IMMUNOHISTOCHEMICAL STUDY [J].