CATALYTIC ANTIBODIES - PERUSING COMBINATORIAL LIBRARIES

被引：27

作者：

POSNER, B

SMILEY, J

LEE, I

BENKOVIC, S

机构：

[1] Department of Chemistry, The Pennsylvania State University, University Park

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 04期

关键词：

D O I：

10.1016/0968-0004(94)90273-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Combinatorial libraries are a promising alternative for isolating catalytic antibodies produced by the immune system in response to the transition-state analog of a given reaction. Large, diverse panels of antibodies with high affinity for the transition-state analog can be isolated using screening or selection approaches. Furthermore, we have estimated that nucleotide sequences that bear close similarity to the sequence for a known catalytic antibody occur in combination at frequencies sufficient for their detection in such libraries.

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页码：145 / 150

页数：6

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