EPITHELIOID HEMANGIOENDOTHELIOMA OF THE LUNG - PLEURAL EFFUSION CYTOLOGY, ULTRASTRUCTURE, AND BRIEF LITERATURE-REVIEW

被引:21
作者
BUGGAGE, RR [1 ]
SOUDI, N [1 ]
OLSON, JL [1 ]
BUSSENIERS, AE [1 ]
机构
[1] JOHNS HOPKINS UNIV HOSP,DEPT PATHOL,BALTIMORE,MD 21205
关键词
EPITHELIOID HEMANGIOENDOTHELIOMA; INTRAVASCULAR BRONCHIOLOALVEOLAR TUMOR; VASCULAR TUMOR; PLEURAL EFFUSION;
D O I
10.1002/dc.2840130112
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Epithelioid hemangioendothelioma (EHE) of the lung is a low-grade malignant tumor of vascular origin initially described under the name intravascular bronchioloalveolar tumor (IVBAT). We present a case of a 44-yr-old Caucasian female with severe radiating back pain, shortness of breath, recurrent malignant pleural effusions, and a negative malignancy workup. Cytopathologic examination of the four pleural fluid specimens revealed large undifferentiated plasmacytoid malignant cells with abundant pink and finely granular cytoplasm round nuclei, and prominent nucleoli. The differential diagnosis based on the cytologic findings included hepatocellular, adrenal, and renal carcinomas, melanoma, mesothelioma, and neuroendocrine tumors. Electron microscopy performed on a pleural fluid specimen and subsequent histologic examination of pleural and lung biopsies established the diagnosis of EHE. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:54 / 60
页数:7
相关论文
共 14 条
[1]  
Corrin B, Manners B, Millard M, Weaver L, Histiogenesis of the so‐called “intravascular bronchioloalveolar tumour.”, J Pathol, 128, pp. 163-167, (1979)
[2]  
Rosai J, Sumner HW, Kostianovsky M, Perez-Mesa C, pp. 83-109, (1976)
[3]  
Dail DH, Liebow AA, Intravascular bronchioloalveolar tumor (ABSTR), Am J Pathol, 78, (1975)
[4]  
Spencer H, Rare pulmonary tumors, Pathology of the lung (excluding pulmonary tuberculosis), 2, pp. 907-909, (1977)
[5]  
Thurlbeck WM, Miscellany, The lung: structure, function and disease, pp. 302-306, (1978)
[6]  
Weldon-Linne CM, Victor TA, Christ ML, Fry WA, Angiogenic nature of the “intravascular bronchioloalveolar tumor” of the lung: an electron microscopic study, Arch Pathol Lab Med, 105, pp. 174-179, (1981)
[7]  
Stein AA, Mauro J, Thibodeau L, Et al., The histiogenesis of cardiac myxomas: relation to other proliferative diseases of subendothelial vasoform reserve cells, Pathology annual, 4, pp. 293-312, (1969)
[8]  
Dail DH, Liebow AA, Gmelich JT, Et al., Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT), Cancer, 51, pp. 452-464, (1983)
[9]  
Bhagavan BS, Eggleston JC, Dorfman HD, Murthy MD, Intravascular bronchioloalveolar tumor (IVBAT): a low‐grade sclerosing epithelioid angiosarcoma of lung, Am J Surg Pathol, 6, pp. 41-52, (1982)
[10]  
Enzinger FM, Weiss SW, Hemangioendothelioma: vascular tumors of intermediate malignancy, Soft tissue tumors, pp. 533-544, (1988)