INTERLEUKIN-1 INHIBITS KERATAN SULFATE PRODUCTION BY RABBIT CHONDROCYTES - POSSIBLE ROLE OF PROSTAGLANDIN-E2

被引：14

作者：

FUKUDA, K

OHTANI, K

DAN, H

TANAKA, S

机构：

[1] Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, 589, Ohnohigashi 377-2, Osaka-sayama

来源：

INFLAMMATION RESEARCH | 1995年 / 44卷 / 04期

关键词：

AGGREGAN; INDOMETHACIN; DEXAMETHASONE;

D O I：

10.1007/BF01782816

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated the importance of prostaglandin E2 (PGE2) release in interleukin-1 (IL-1)-induced inhibition of aggrecan synthesis by chondrocytes. Keratan sulfate (KS) production was measured in parallel with PGE2 release in chondrocytes. IL-1 inhibited KS production and stimulated PGE2 release. In the presence of PGE2, there was a dose-dependent decrease in baseline KS production. Indomethacin and dexamethasone partially blocked the IL-1-induced PGE2 release while KS production recovered. Our results suggest that IL-1 inhibits KS production, in part, by stimulating the release of PGE2.

引用

页码：178 / 181

页数：4

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