The emerging role of MIF in septic shock and infection

被引:39
作者
Bernhagen, J
Calandra, T
Bucala, R
机构
[1] The Picower Institute for Medical Research, Manhassett, New York
关键词
MIF septic shock; infection; cytokines; pituitary endotoxin;
D O I
10.1007/BF01878495
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The protein mediator described originally as macrophage migration inhibitory factor (MIF) has been ''re-discovered'' recently to be both a novel pituitary hormone and a pro-inflammatory, macrophage-derived cytokine. Emerging studies indicate that MIF plays a pivotal role not only in endotoxic shock but also in the host response to a variety of acute and chronic infections.
引用
收藏
页码:123 / 127
页数:5
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