FUNCTIONAL ACTIVITY OF SWEAT GLANDS OF MOUSE

Using the iodine-starch method for visualizing sweat, the functional activity of the eccrine sweat glands of the mouse foot-pads was studied. The sweat glands of the pad were stimulated by local injection of parasym - pathomimetic agents, such as acetylcholine, carbaminoylcholine, mecholyl and pilocarpine, and sympathomimetic ones, such as adrenaline, noradrenaline and iso propylnoradrenaline. In general, the parasympathomimetic agents were more effective in eliciting sweat responses than the sympathomimetic ones. The fact that spontaneous sweating was eliminated by relatively low con centrations of atropine, but not by relatively high concentrations of dihydro ergotamine suggests that the sweat glands of the plantar surface of the mouse receive a cholinergic nerve supply. Nicotine and lobeline, injected intradermally, did not provoke an axon reflex sweating. © 1968, Tohoku University Medical Press. All rights reserved.