EFFECT OF CHEMICAL MODIFICATION OF L-ASPARAGINASE ON ITS PERSISTENCE IN CIRCULATING BLOOD OF ANIMALS

被引：29

作者：

BENBOUGH, JE

WIBLIN, CN

RAFTER, TNA

LEE, J

机构：

[1] Microbiological Research Establishment, Porton Down, Salisbury

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 06期

关键词：

D O I：

10.1016/0006-2952(79)90366-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The persistence in circulating blood of rabbits and mice of Erwinia carovotora asparaginase and some of its chemically modified derivatives was compared. Derivatives of various molecular size were obtained by reacting the enzyme with some bifunctional reagents and activated dextrans. The persistence of the larger molecular weight derivatives of the enzyme was many-fold higher than that of the native enzyme. Radioactive labelling of the enzyme showed that it may be removed intact from the circulation. © 1979.

引用

页码：833 / 839

页数：7

共 26 条

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