METHYLMERCURY BINDS TO A LOW-MOLECULAR WEIGHT SUBSTANCE IN RABBIT AND HUMAN-ERYTHROCYTES

被引：59

作者：

NAGANUMA, A ^{[1
]}

IMURA, N ^{[1
]}

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,DEPT PUBL HLTH,MINATO KU,TOKYO 108,JAPAN

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1979年 / 47卷 / 03期

关键词：

D O I：

10.1016/0041-008X(79)90532-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Behavior of methylmercury in animal blood was investigated by gel filtration of stroma-free hemolysates from rat, rabbit, and human erythrocytes, treated with methylmercury. In the rabbit and human erythrocytes, methylmercury was bound to a low molecular weight substance rather than hemoglobin, while almost all of methylmercury in the rat erythrocyte was bound to the hemoglobin fraction. The methylmercury-bound substance of low molecular weight in rabbit erythrocytes showed a similar behavior pattern to that of glutathione (GSH) bound with methylmercury on gel filtration with Sephadex G-15 and thin-layer chromatography. © 1979.

引用

页码：613 / 616

页数：4

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