THE CANDIDATE PROTOONCOGENE BCL-3 IS RELATED TO GENES IMPLICATED IN CELL LINEAGE DETERMINATION AND CELL-CYCLE CONTROL

被引：438

作者：

OHNO, H ^{[1
]}

TAKIMOTO, G ^{[1
]}

MCKEITHAN, TW ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637

来源：

CELL | 1990年 / 60卷 / 06期

关键词：

D O I：

10.1016/0092-8674(90)90347-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A gene, bcl-3, is found on chromosome 19 adjacent to the breakpoints in the translocation t(14;19)(q32;q13.1), which occurs in some cases of chronic lymphocytic leukemia. Sequence analysis of the human bcl-3 gene predicts a protein containing seven tandem copies of the SW16 cdc10 motif. This motif was previously identified in yeast genes that regulate events at the start of the cell cycle and in invertebrate transmembrane proteins involved in cell differentiation pathways. Expression of bcl-3 in normal blood cells increases markedly following mitogenic stimulation, and leukemic cells with the translocation show much greater expression than controls. These results suggest that bcl-3 is a proto-oncogene that may contribute to leukemogenesis when abnormally expressed. © 1990.

引用

页码：991 / 997

页数：7

共 31 条

[1] THE YEAST SW14 PROTEIN CONTAINS A MOTIF PRESENT IN DEVELOPMENTAL REGULATORS AND IS PART OF A COMPLEX INVOLVED IN CELL-CYCLE-DEPENDENT TRANSCRIPTION [J].