REGULATION OF HEAT-SHOCK PROTEIN-SYNTHESIS IN RAT ASTROCYTES

被引：29

作者：

DWYER, BE

NISHIMURA, RN

DEVELLIS, J

CLEGG, KB

机构：

[1] VET ADM MED CTR,INVITRO REMYELINAT LAB,SEPULVEDA,CA 91343

[2] VET ADM MED CTR,HYPERTENS RES LAB,SEPULVEDA,CA 91343

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,SCH MED,DEPT ANAT & PSYCHIAT,LOS ANGELES,CA 90024

[5] UNIV CALIF LOS ANGELES,SCH MED,BRAIN RES INST,LOS ANGELES,CA 90024

[6] UNIV CALIF LOS ANGELES,SCH MED,MENTAL RETARDAT RES CTR,LOS ANGELES,CA 90024

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1991年 / 28卷 / 03期

关键词：

GENE EXPRESSION; GENE REGULATION; BRAIN INJURY; GLIAL CELLS;

D O I：

10.1002/jnr.490280306

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rat forebrain astrocytes synthesize heat shock proteins with molecular weights 97, 89, 70, 68, and 30-34 kilodaltons. The stress inducible 68-kDa heat shock protein (HSP-68) was vigorously expressed by astrocytes in culture after a 45-degrees-C, 20 min heat shock. HSP-68 synthesis was poorly inducible by a second heat shock given 16 hr after the initial heat shock. Decreased [S-35]methionine incorporation into HSP-68 correlated with low levels of HSP-68 mRNA present after the second heat shock. The data suggest that control of HSP-68 mRNA levels by transcriptional/posttranscriptional mechanisms is a major site for regulation of HSP-68 synthesis.

引用

页码：352 / 358

页数：7

共 40 条

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