CALBINDIN D-28K AND PARVALBUMIN IMMUNOREACTIVITY IN THE FRONTAL-CORTEX IN PATIENTS WITH FRONTAL-LOBE DEMENTIA OF NON-ALZHEIMER TYPE ASSOCIATED WITH AMYOTROPHIC-LATERAL-SCLEROSIS

被引:45
作者
FERRER, I [1 ]
TUNON, T [1 ]
SERRANO, MT [1 ]
CASAS, R [1 ]
ALCANTARA, S [1 ]
ZUJAR, MJ [1 ]
RIVERA, RM [1 ]
机构
[1] HOSP NAVARRA,SERV ANAT PATOL,PAMPLONA,SPAIN
关键词
D O I
10.1136/jnnp.56.3.257
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.
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页码:257 / 261
页数:5
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