SEQUENCE IDENTIFICATION OF 2,375 HUMAN BRAIN GENES

被引：729

作者：

ADAMS, MD ^{[1
]}

DUBNICK, M ^{[1
]}

KERLAVAGE, AR ^{[1
]}

MORENO, R ^{[1
]}

KELLEY, JM ^{[1
]}

UTTERBACK, TR ^{[1
]}

NAGLE, JW ^{[1
]}

FIELDS, C ^{[1
]}

VENTER, JC ^{[1
]}

机构：

[1] NINCDS,RECEPTOR BIOCHEM & MOLEC BIOL SECT,BETHESDA,MD 20892

来源：

NATURE | 1992年 / 355卷 / 6361期

关键词：

D O I：

10.1038/355632a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

WE recently described a new approach for the rapid characterization of expressed genes by partial DNA sequencing to generate 'expressed sequence tags' 1. From a set of 600 human brain complementary DNA clones, 348 were informative nuclear-encoded messenger RNAs. We have now partially sequenced 2,672 new, independent cDNA clones isolated from four human brain cDNA libraries to generate 2,375 expressed sequence tags to nuclear-encoded genes. These sequences, together with 348 brain expressed sequence tags from our previous study, comprise more than 2,500 new human genes and 870,769 base pairs of DNA sequence. These data represent an approximate doubling of the number of human genes identified by DNA sequencing and may represent as many as 5% of the genes in the human genome.

引用

页码：632 / 634

页数：3

共 19 条

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